Bcor gene functional study

The corepressors BCOR and BCORL1: two novel players in ...

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BCOR mutations were demonstrated to be clonal, somatic, disruptive events involving the only functional allele, not only in male but also in female AML patients. 8 Notably, the features of BCOR mutations in AML closely resembled those of the germline BCOR disruptive mutations causing the oculo-facio-cardio-dental (OFCD) X-linked syndrome 18 ...

The corepressors BCOR and BCORL1: two novel players in ...

Bcor loss perturbs myeloid differentiation and promotes ...

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3/22/2019 · The BCL6 Co-repressor (BCOR) gene is located on chromosome X and encodes a ~180 kDa nuclear protein that is ubiquitously expressed across adult human tissues.BCOR is …

Bcor loss perturbs myeloid differentiation and promotes ...

Genomic characterisation of Eμ-Myc mouse lymphomas ...

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3/6/2017 · The recurrence of inactivating BCOR mutations in human tumours, a recent in vitro study showing that BCOR regulates myeloid cell proliferation and …

Genomic characterisation of Eμ-Myc mouse lymphomas ...

Structure of the Polycomb Group ... - PubMed Central (PMC)

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4/2/2013 · Bcor is required for appropriate regulation of gene expression during differentiation mouse embryonic stem cells (Wamstad, et al., 2008). BCOR is involved in mediating transcriptional repression by the oncoprotein BCL6 and thus likely plays an active role in the development of BCL6-driven lymphomas (Gearhart, et al., 2006; Huynh, et al., 2000).

Structure of the Polycomb Group ... - PubMed Central (PMC)

Recurrent EP300-BCOR Fusions in Pediatric Gliomas With ...

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The BCOR gene, located on ... Schematic of p300 and BCOR protein functional domains with breakpoints shown for each case. (C) Resulting fusion genes illustrated by exon numbers. The raw DNA sequence split reads are shown to the right of each. ... The gliomas with EP300-BCOR fusions in this study had an infiltrative growth pattern, frequent ...

Recurrent EP300-BCOR Fusions in Pediatric Gliomas With ...

Identification of nuclear localization signals within the ...

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Mutations in theBCL-6 corepressor (BCOR) gene, which encodes a transcriptional corepressor, were described to cause oculofaciocardiodental syndrome (MIM300166). The purpose of this study was to localize the classical nuclear localization signals (NLSs) of the BCOR using reported human BCOR mutations with comparable phenotypes.

Identification of nuclear localization signals within the ...

BCoR-L1 variation and breast cancer | Breast Cancer ...

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8/16/2007 · BCoR-L1 has been shown to play a role in transcription corepression, and expression of the X-linked BCoR-L1 gene has been reported to be dysregulated in breast cancer subjects. BCoR-L1 is located on the X chromosome and is subject to X inactivation.

BCoR-L1 variation and breast cancer | Breast Cancer ...

Internal deletion of BCOR reveals a tumor suppressor ...

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Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies Article (PDF Available) in Journal of Experimental Medicine 214(10):jem.20170167 · August 2017 ...

Internal deletion of BCOR reveals a tumor suppressor ...

Identification of nuclear localization signals within the ...

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10/24/2015 · Mutations in the BCL-6 corepressor (BCOR) gene, which encodes a transcriptional corepressor, were described to cause oculofaciocardiodental syndrome (MIM 300166).The purpose of this study was to localize the classical nuclear localization signals (NLSs) of the BCOR using reported human BCOR mutations with comparable phenotypes. The genotype–phenotype correlation among …

Identification of nuclear localization signals within the ...

Fusion of the ZC3H7B and BCOR genes in endometrial stromal ...

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Fusion of the ZC3H7B and BCOR genes in endometrial stromal sarcomas carrying an X;22-translocation Article in Genes Chromosomes and Cancer 52(7) · April 2013 with 175 Reads DOI: 10.1002/gcc.22057 ...

Fusion of the ZC3H7B and BCOR genes in endometrial stromal ...

BCOR 101 Exam 1 Flashcards | Quizlet

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Start studying BCOR 101 Exam 1. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Search. ... -nonfunctional relatives of functional genes ... BCOR 101 Exam 2. 38 terms. BCOR 101 Final: Chapter 17 and 18. 181 terms. Exam #1 (Chpt. 1-4) 107 terms. BCOR 101 Exam 1.

BCOR 101 Exam 1 Flashcards | Quizlet

BCoR, a novel corepressor involved in BCL-6 repression

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The BCL-6 gene was originally identified because of its involvement in chromosomal translocations ... Having shown that BCL-6 can interact with BCoR and BCoR-S, we wanted to determine the functional role of these proteins. ... In this study we have shown that BCoR interacts with BCL-6 and potentiates transcriptional repression by BCL-6 with ...

BCoR, a novel corepressor involved in BCL-6 repression

Gene Detail - JAX CKB

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BCOR mutant indicates an unspecified mutation in the BCOR gene. P844S missense: unknown: BCOR P844S does not lie within any known functional domains of the Bcor protein (UniProt.org). P844S has not been characterized in the scientific literature and therefore, its effect on Bcor protein function is unknown (PubMed, Feb 2019). R1131L missense

Gene Detail - JAX CKB

Whole-exome sequencing identifies somatic mutations of ...

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The BCOR gene—initially identified as a BCL6 transcriptional corepressor 27 —was recently found to translocate with RARA in acute promyelocytic leukemia. 28 The YY2 gene 29 shares many structural and functional features with YY1, the transcriptional repression activity of which is under control of the NPM1 gene, 30 which is frequently ...

Whole-exome sequencing identifies somatic mutations of ...

A Non-canonical BCOR-PRC1.1 Complex Represses ...

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A Non-canonical BCOR-PRC1.1 Complex Represses Differentiation Programs in Human ESCs. ... BCOR is an X-linked gene; thus, only one allele was targeted in H1 (XY) ... I and 4K). Thus, the BCOR-PRC1.1 complex appeared to be fully functional at a subset of BCOR-PRC1.1 targets in KDM2B-KO hESCs.

A Non-canonical BCOR-PRC1.1 Complex Represses ...

BCOR 012 Exam 1 Flashcards | Quizlet

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BCOR 012 Exam 1 study guide by aarchang includes 183 questions covering vocabulary, terms and more. Quizlet flashcards, activities and games help you improve your grades. ... different forms of a gene existing at a particular chromosomal locus ... copies of genes that are no longer functional but evolved from functional genes.

BCOR 012 Exam 1 Flashcards | Quizlet

Left-sided embryonic expression of the BCL-6 corepressor ...

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5/21/2007 · To study the function of BCOR, we used morpholino oligonucleotides ... (xtBcor) of the human BCOR gene from the X. tropicalis genome project database. The sequences were conserved, with the same exon number, exon/intron boundaries and identically positioned translation initiation sites. ... the functional requirement for a molecule on the ...

Left-sided embryonic expression of the BCL-6 corepressor ...

BCoR-L1: an X-linked transcriptional co-repressor in which ...

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BCoR-L1 encodes a right ventricular conduction delay and a very short P-R interval. ... but less severe symptoms, and HDAC class II proteins to regulate downstream gene transcription and their mother with similar clinical features died at age 29 of (eg, E-cadherin). ... as it to differentiate neural cells to study structural/functional changes ...

BCoR-L1: an X-linked transcriptional co-repressor in which ...

(PDF) BCoR-L1 variation and breast cancer | Gulietta Pupo ...

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However, a study BCoR-L1 expression in cancer and normal cell lines using a BCoR-L1-containing Affymetrix microarray (Affymetrix, To assess a possible role for BCoR-L1 in tumourigenesis, we Santa Clara, CA, USA) did not provide any evidence for also analysed BCoR-L1 expression in various ovarian, breast, BCoR-L1 deregulation in ovarian cancers ...

(PDF) BCoR-L1 variation and breast cancer | Gulietta Pupo ...

Identification of nuclear localization signals within the ...

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Mutations in theBCL‐6 corepressor (BCOR) gene, which encodes a transcriptional corepressor, were described to cause oculofaciocardiodental syndrome (MIM300166).The purpose of this study was to localize the classical nuclear localization signals (NLSs) of the BCOR using reported humanBCOR mutations with comparable phenotypes. The genotype–phenotype correlation among the mutations …

Identification of nuclear localization signals within the ...

Activin Regulates Self-renewal and Differentiation of ...

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9/4/2015 · The development of a functional placenta is largely dependent upon proper proliferation and differentiation of trophoblast stem cells (TSCs). ... In the present study, we provided evidence that Bcor is a downstream target of activin signaling and plays an important role in self-renewal ... it is possible that BCOR could regulate gene expression ...

Activin Regulates Self-renewal and Differentiation of ...

Clear cell sarcomas of the kidney are characterised by ...

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Aims. Clear cell sarcoma of the kidney (CCSK) is a rare paediatric renal malignant tumour. The majority of CCSKs have internal tandem duplications (ITDs) of the BCOR gene, whereas a minority have the YWHAE–NUTM2 gene fusion. A third ‘double‐negative’ (DN) category comprises CCSKs with neither BCOR ITDs nor YWHAE–NUTM2 fusion. The aim of this study was to characterise 11 ...

Clear cell sarcomas of the kidney are characterised by ...

Research Paper Activation of the basal cell carcinoma ...

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The objective of this study was to identify and validate pathways ... In summary, these results provide functional evidence of altered BCOR expression and homogeneous coactivation of both the SHH and WNT signaling pathways, building ... (BCOR) gene and by BCOR overexpression [1]. Preliminary survival data suggest that the CNS

Research Paper Activation of the basal cell carcinoma ...

Clarifying the Impact of Polycomb Complex Component ...

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Clarifying the Impact of Polycomb Complex Component Disruption in Human Cancers Yukiya Yamamoto, Akihiro Abe, and Nobuhiko Emi Abstract The dysregulation of proper transcriptional control is a major cause of developmental diseases and cancers. Polycomb proteins form chromatin-modifying complexes that transcriptionally silence genome regions in ...

Clarifying the Impact of Polycomb Complex Component ...

Research Paper Inhibition of the transcriptional repressor ...

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overexpression of Bcl-6 or BCoR leads to the formation of nuclear aggregates [34]. Subsequent functional assays were therefore based on gene silencing rather than overexpression to reveal the properties of the endogenous proteins. Figure 1: Endothelial Bcl-6/BCoR mRNA expression in response to tumor-derived stimuli. (A) Bcl-6/BCoR mRNA levels

Research Paper Inhibition of the transcriptional repressor ...

Open Access BCoR-L1 variation and breast cancer

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an X-linked gene may be involved in these male cancer because males carry only one copy of the X chromosome and because BCoR-L1 has been found to be expressed highly in the prostate [10]. A small number of breast cancer families in which the affected individuals showed haplotype sharing around the BCoR-L1 locus were also includ ed in this study. In

Open Access BCoR-L1 variation and breast cancer

A Non-canonical BCOR-PRC1.1 Complex Represses ...

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Molecular networks responsible for the maintenance of primed pluripotency in human embryonic stem cells (hESCs) remain poorly defined. Wang et al. identify BCOR as a critical hESC regulator that defines a subtype of the PRC1.1 complexes with distinct recruitment and repression mechanisms that are essential for silencing differentiation programs in hESCs.

A Non-canonical BCOR-PRC1.1 Complex Represses ...
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