Affirm atrial fibrillation study

A Comparison of Rate Control and Rhythm Control in ...

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Atrial fibrillation is the most common sustained cardiac arrhythmia, yet the optimal strategy for its management remains uncertain. 1-4 During atrial fibrillation, most symptoms (but perhaps not ...

A Comparison of Rate Control and Rhythm Control in ...

The AFFIRM trial: Rate-control vs. rhythm-control in ...

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Study Rundown: Originally published in 2002, the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) trial compared two common strategies for managing atrial fibrillation: rhythm-control and rate-control. Patients were anticoagulated in both approaches to address the increased ...

The AFFIRM trial: Rate-control vs. rhythm-control in ...

Baseline characteristics of patients with atrial ...

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Most patients with recurrent episodes had symptoms with atrial fibrillation. Approximately one third of patients were enrolled with a first episode of atrial fibrillation. CONCLUSION: The AFFIRM Study enrolled 4060 predominantly elderly patients with atrial fibrillation to compare ventricular rate …

Baseline characteristics of patients with atrial ...

The New England Journal of Medicine - nejm.org

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of Rhythm Management (AFFIRM) study, we com-pared the effects of long-term treatment with these two strategies. ... atrial fibrillation was assessed both at rest and during activity, which

The New England Journal of Medicine - nejm.org

The Atrial Fibrillation Follow-up Investigation of Rhythm ...

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4/7/2004 · Objectives. We sought to evaluate approaches used to control rate, the effectiveness of rate control, and switches from one drug class to another in the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study.

The Atrial Fibrillation Follow-up Investigation of Rhythm ...

The Atrial Fibrillation Follow-up Investigation of Rhythm ...

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The Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study was a large, mul-ticenter, randomized trial sponsored by the National Heart, Lung, and Blood Institute. This trial compared rate-control therapy with rhythm-control therapy to treat …

The Atrial Fibrillation Follow-up Investigation of Rhythm ...

The Atrial Fibrillation Follow-up Investigation of Rhythm ...

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4/7/2004 · The Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study was a large, multicenter, randomized trial sponsored by the National Heart, Lung, and Blood Institute. This trial compared rate-control therapy with rhythm-control therapy to treat AF in a population at high risk of stroke or death . The primary goal was to ...

The Atrial Fibrillation Follow-up Investigation of Rhythm ...

Atrial Fibrillation in the Post-AFFIRM World - uscjournal.com

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Atrial fibrillation (AF) is the most common cardiac arrhythmia encountered in clinical practice. The prevalence of AF increases with age; 1 one and approximately 2.3 million US adults are currently afflicted with AF, with that number projected to increase to 5.6 million by the year 2050. 2 AF typically results in an irregular rhythm with poorly controlled ventricular rate and loss of atrial ...

Atrial Fibrillation in the Post-AFFIRM World - uscjournal.com

Atrial Fibrillation Follow-up Investigation of Rhythm ...

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Olshansky B, Heller EN, Mitchell LB, Chandler M, Slater W, Green M, Brodsky M, Barrell P, Greene HL. Are transthoracic echocardiographic parameters associated with atrial fibrillation recurrence or stroke? Results from the Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) study. J Am Coll Cardiol. 2005 Jun 21;45(12):2026-33.

Atrial Fibrillation Follow-up Investigation of Rhythm ...

BioLINCC: Atrial Fibrillation Follow-Up Investigation of ...

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Objectives. The Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) trial sought to compare total mortality between two treatment strategies for Atrial Fibrillation: maintenance of sinus rhythm, or ventricular response rate control.

BioLINCC: Atrial Fibrillation Follow-Up Investigation of ...

Baseline characteristics of patients with atrial ...

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Most patients with recurrent episodes had symptoms with atrial fibrillation. Approximately one third of patients were enrolled with a first episode of atrial fibrillation. Conclusion The AFFIRM Study enrolled 4060 predominantly elderly patients with atrial fibrillation to compare ventricular rate control with rhythm control. The patients in the ...

Baseline characteristics of patients with atrial ...

The Atrial Fibrillation Follow-up Investigation of Rhythm ...

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4/7/2004 · BACKGROUND: The AFFIRM study showed that atrial fibrillation (AF) can be treated effectively with rate control and anticoagulation, but drug efficacy to control rate remains uncertain. METHODS: Patients (n = 2,027) randomized to rate control in the AFFIRM study were given rate-controlling drugs by their treating physicians.

The Atrial Fibrillation Follow-up Investigation of Rhythm ...

Relationships Between Sinus Rhythm, Treatment, and ...

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Background— The AFFIRM Study showed that treatment of patients with atrial fibrillation and a high risk for stroke or death with a rhythm-control strategy offered no survival advantage over a rate-control strategy in an intention-to-treat analysis. This article reports an “on-treatment” analysis of the relationship of survival to cardiac rhythm and treatment as they changed over time.

Relationships Between Sinus Rhythm, Treatment, and ...

Atrial Fibrillation -Post-AFFIRM Era - ECR Journal

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However, several studies, the largest of which is the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study, have failed to confirm the anticipated benefits of a rhythm-control strategy, a clinical dilemma that will be discussed further in this review.

Atrial Fibrillation -Post-AFFIRM Era - ECR Journal

Atrial Fibrillation | AP Cardiology

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3/14/2019 · In 2002, NEJM published the AFFIRM trial, showing no difference in outcomes between patients with atrial fibrillation treated with rate or rhythm control strategy. But does that mean rate control should be the default treatment method? In this episode I discuss this topic with Dr. Mitch Faddis and Dr. Philip Cuculich and their approach to …

Atrial Fibrillation | AP Cardiology

Atrial Fibrillation: Beyond the AFFIRM trial - Ohio-ACC

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Atrial Fibrillation: Beyond the AFFIRM trial Daniel J. Cantillon MD FACC FHRS Cardiac Electrophysiology and Pacing Assistant Professor, Lerner College of Medicine Cleveland Clinic, Heart & Vascular Institute

Atrial Fibrillation: Beyond the AFFIRM trial - Ohio-ACC

Alternative endpoints for mortality in studies of patients ...

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Atrial Fibrillation Follow-up Investigation of Rhythm Man-agement (AFFIRM) study, the annual death rate was less than 5% per year5 compared to approximately 10% per year in the AVID trial.6 Furthermore, the cause-specific mortal-ities in AFFIRM and AVID were quite different.7,8 The imperative for using clinical endpoints in trials of AF has

Alternative endpoints for mortality in studies of patients ...

Randomized Evaluation of Atrial Fibrillation Treatment ...

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10/24/2014 · The study is a prospective, multicenter, randomized study to assess the safety and effectiveness of FIRM procedures followed by conventional ablation including PVI versus a standard PVI procedure for the treatment of persistent atrial fibrillation.

Randomized Evaluation of Atrial Fibrillation Treatment ...

GUIDELINES FOR ATRIAL FIBRILLATION MANAGEMENT: ROLE OF …

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2006.1 Among these trials were the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM)3 and the Rate Control vs. Electrical cardio-version for persistent atrial fibrillation (RACE)14 trials, which were the first to evaluate the effects of rate vs. rhythm on morbidity and mortality as the primary outcome.

GUIDELINES FOR ATRIAL FIBRILLATION MANAGEMENT: ROLE OF …

Premier Health – FAQs – Atrial Fibrillation

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It is not uncommon for someone with atrial fibrillation to be asymptomatic. A 2005 Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study compared patients with atrial fibrillation who were asymptomatic and those who experienced a variety of symptoms.

Premier Health – FAQs – Atrial Fibrillation

Atrial fibrillation and blood pressure: more than just a ...

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8/28/2017 · The study was a post-hoc analysis of the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) trial, a prospective randomized comparison of two …

Atrial fibrillation and blood pressure: more than just a ...

The AFFIRM study: Approaches to control rate in atrial ...

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The AFFIRM study showed that atrial fibrillation (AF) can be treated effectively with rate control and anticoagulation, but drug efficacy to control rate remains uncertain.

The AFFIRM study: Approaches to control rate in atrial ...

Baseline characteristics of patients with atrial ...

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Baseline characteristics of patients with atrial ...

Baseline characteristics of patients with atrial ...

UpToDate

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- Recurrent AF after amiodarone propafenone and sotalol - Rhythm versus rate control AF AFFIRM - Rhythm versus rate control AF RACE - Prevalence of atrial fibrillation with age RELATED TOPICS. Patient education: Atrial fibrillation (Beyond the Basics) Antiarrhythmic drugs to maintain sinus rhythm in patients with atrial fibrillation: Clinical trials

UpToDate

Atrial Fibrillation:When - and How - to Convert to Sinus ...

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4/1/2006 · Your patient with atrial fibrillation (AF) is hemodynamically stable and you have successfully established rate control. Your next step is to weigh the risks and benefits of attempting to restore sinus rhythm. In up to one half of patients, AF of recent onset converts spontaneously to normal sinus rhythm within 24 hours. Thus, in some cases, the most appropriate approach may

Atrial Fibrillation:When - and How - to Convert to Sinus ...

Dronedarone for atrial fibrillation: How does it compare ...

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Dronedarone for atrial fibrillation: How does it compare with amiodarone? ... and survival in the Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) study. Circulation 2004; ... the Efficacy and safety of dRonedArone for the cOntrol of ventricular rate …

Dronedarone for atrial fibrillation: How does it compare ...

Case Study 2: Patient With Atrial Fibrillation ... - Medscape

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The Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study: approaches to control rate in atrial fibrillation. J Am Coll Cardiol . 2004;43:1201-1208. Cordina J, Mead G. Pharmacological cardioversion for atrial fibrillation and flutter.

Case Study 2: Patient With Atrial Fibrillation ... - Medscape

Arrhythmic complications after electrical cardioversion of ...

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It is known that those with asymptomatic AF have a lower incidence of CHF. 16 x 16 Flaker, G.C., Belew, K., Beckman, K. et al. Asymptomatic atrial fibrillation: demographic features and prognostic information from the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study.

Arrhythmic complications after electrical cardioversion of ...

Patient-reported triggers of paroxysmal atrial fibrillation

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11/2/2004 · The authors used data from a study called AFFIRM (Atrial Fibrillation Follow-up Investigations of Rhythm Management) to estimate what would happen to patients who received each type of treatment. The results might be different for patients who are younger than or differ in other ways from the patients in the AFFIRM study.

Patient-reported triggers of paroxysmal atrial fibrillation

Cost-Effectiveness of Rate Control vs. Rhythm Control for ...

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For example, at 5 years of follow-up, only 62.6% of AFFIRM enrollees randomized to rhythm control remained in SR. In comparison, of the 100 participants in the Strategies of Treatment in Atrial Fibrillation Study (STAF) 18 assigned to rhythm control, only 23% remained in SR at 3 years’ follow-up .

Cost-Effectiveness of Rate Control vs. Rhythm Control for ...

Atrial Fibrillation and Heart Failure - Larned - 2009 ...

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The Planning and Steering Committees of the AFFIRM Study for the rate control in chronic atrial fibrillation during daily activity and NHLBI AFFIRM Investigators. Atrial fibrillation follow-up investi- programmed exercise: a crossover open-label study of five drug gation of rhythm management—the AFFIRM study design.

Atrial Fibrillation and Heart Failure - Larned - 2009 ...

The Atrial Fibrillation Follow-up Investigation of Rhythm ...

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ABSTRACTDronedarone (Multaq), an analogue of amiodarone (Cordarone), was designed to cause fewer adverse effects than the parent compound. Studies have indeed shown dronedarone to be safer than amiodarone, but less effective. Its official indication is to reduce the risk of hospitalization in patients with paroxysmal or persistent atrial fibrillation or atrial flutter and other cardiovascular ...

The Atrial Fibrillation Follow-up Investigation of Rhythm ...

Dronedarone for atrial fibrillation: How does it compare ...

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12/23/2013 · QRS duration was retrieved from the baseline electrocardiograms of patients enroled in the Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) study and divided into three categories: <90, 90–119, ≥120 ms. Cox models were applied relating the hazards of mortality and hospitalizations to QRSd.

Dronedarone for atrial fibrillation: How does it compare ...

QRS duration predicts death and hospitalization among ...

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In the AFFIRM study (Atrial Fibrillation Follow-up Investigation of Rhythm Management), an insignificant trend toward increased mortality was noted in the rate control group, and importantly, no evidence suggested that the rhythm-control strategy protected patients from stroke.

QRS duration predicts death and hospitalization among ...

Atrial Fibrillation - Medscape

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tients With Atrial Fibrillation Versus Long Term Warfarin Therapy trial; PROTECT AF = Watchman Left Atrial Appendage System for Embolic Protection in Patients with Atrial Fibrillation; RCT = ran-domized controlled trial; RE-ALIGN = Randomized, Phase II Study to …

Atrial Fibrillation - Medscape

Antithrombotic Therapy for Atrial Fibrillation

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The management of atrial fibrillation (AF) is focused on preventing temporary circulatory instability and to prevent stroke and other ischemic events. Control of heart rate and rhythm are principally used to achieve the former, while anticoagulation may be employed to decrease the risk of stroke.

Antithrombotic Therapy for Atrial Fibrillation

Management of atrial fibrillation - Wikipedia

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Case Study 65 year old female with a history of dyslipidemia presents to your office with complaints of palpitations that started last evening. No other past medical history. She admits to similar episodes on and off for the last few months • Patient was found to be in atrial fibrillation with a rate of 114 bpm.

Management of atrial fibrillation - Wikipedia
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